Dear All: 

Institute of Molecular Medicine
School of Life Sciences
Center for Life Sciences
Research Seminar

 

Title：Transcriptional regulation in cardiovascular system development and disease

 

Speaker：William T. Pu, M.D.

                Professor of Pediatrics

                Department of Cardiology, Boston Children’s Hospital, Harvard Medical School, USA

 

Time：2016年6月22日（星期三）下午1:00-2:30

 

Place：北京大学金光生命科学大楼101报告厅

 

Host：北京大学分子医学研究所     何爱彬(Tel. 6276-7275)

 

Abstract: Formation and function of the cardiovascular system is under exquisite transcriptional control. Using a combination of functional genetic, transcriptomic, and epigenomic approaches the Pu lab has been investigating the molecular mechanisms of transcriptional regulation in the heart and vascular systems. In this talk I will summarize some of the findings: (1) mapping of dynamic changes in transcription factor complexes and binding sites through heart development and disease; (2) post-transcriptional regulation of transcription factor complexes in and their effects on heart growth; and (3) development of a Cre-directed method for cell type specific enhancer identification and its application to studying transcriptional regulation of blood vessel formation and homeostasis.