血液流变学研究中心成立于1993年。1997年我中心与美国加州大学圣地亚戈分校（UCSD）钱煦教授领导的分子生物工程实验室结成联合血液流变学研究中心。2003年又与UCSD生物工程系建立血液流变学生物信息学联合研究中心。

　　课题组主要研究血液流变学、血液循环力学和细胞生物力学，从研究生理和病理状态下的细胞力学特性的变化及其分子机制出发，以期找到结构-力学特性-生物功能-疾病状态的关系。本课题组以血液细胞为研究对象，研究正常生理条件和病生理条件下血液细胞的力学响应以及生物力学特性。我们采用激光衍射法和微吸管吮吸技术等先进的生物力学和生物物理学研究方法，并结合细胞和分子生物学技术，(1)研究血液细胞（包括红细胞和树突状细胞）的发育过程中生物力学特性的变化规律，(2)研究血液肿瘤细胞在转抑癌基因前后其生物力学特性的改变，(3)研究肿瘤微环境下树突状细胞的生物力学特性的变化，(4)以细胞骨架蛋白为切入点，研究细胞生物力学的分子基础。

　　血液流变学中心由一名教授、四名副教授及研究生组成。本中心研制了多种流变学仪器，其中包括新型激光衍射仪、初始流量法核孔滤膜仪、双向旋转流变仪、电导法红细胞流变特性测试仪等，还自行装配了测量单细胞粘弹性的微吸管测试系统。激光衍射仪在1993年被定为国家级新产品，1997年获地矿部三等奖。电导法红细胞流变特性测试仪获得国内新型专利。我中心的研究成果获得1999年教育部科学进步三等奖，2000年北京市科学进步二等奖，2015年贵州省科学技术奖三等奖。本中心博士生硕士生获得过多个奖项，包括：2001年全国生物流变学优秀论文奖、2004年北京大学优秀博士论文奖、2003年北京市“三号学生”及“五四”奖学金、2006年北京大学“五四奖章”，以及由国际生物流变学和血液流变学大会颁发的“Chien-Fung”奖。

　　中心主要科研成果包括：（1）首次发现原红、早、晚幼红细胞、网织红细胞发育成熟过程的生命突变阶段中细胞微观流变学特性及其生物物理特性存在突变，并提出一种同步动态研究红细胞生长过程的新动物模型；（2）首次从血液流变学角度研究了抑癌基因对肿瘤细胞的影响，发现抑癌基因可以通过改变细胞骨架结构来抑制肿瘤细胞的变形和迁移；（3）首次发现单核细胞发育为未成熟和成熟树突状细胞过程中其流变学特性发生显著的变化，并且发现肿瘤细胞微环境引起的细胞骨架相关基因、蛋白的表达改变是造成树突状细胞流变学及免疫功能恶化的重要原因。我中心已发表SCI论文100余篇，受到Blood、Diabetes、Advances in Cancer Research、Arteriosclerosis Thrombosis and Vascular Biology、Biophysical Journal等多种杂志的引用和支持。

　　

　　机构负责人：姚伟娟

　　联系人：姚伟娟

　　邮箱：weijuanyao@bjmu.edu.cn

　　电话：82802419

　　地址：生理楼211（里面）

　　网址链接：http://hemorheology.bjmu.edu.cn/

　　

　　

 

　　Hemorheology Center

 

　　Hemorheology center was established in 1993. In 1997, we collaborated with the Molecular Bioengineering lab led by Dr. Shu Chien at Unviersity of California, San Diego (UCSD) and founded united hemorheology research center. In 2003, we founded Hemorheology Bioinformatics Research Center with Department of Bioengineering at UCSD.

　　We are aimed to study hemorheology, hemodynamics, and cell biomechanics. We investigate the changes of cell mechanical properties under physiological and pathophysiological states and its underlying mechanisms to explore the relationships between structure, mechanics, biological functions, and diseases. We focus on blood cells and study their mechanical responses and mechanical properties under physiological and pathophysiological conditions. By utilizing ektacytometry, micropipette, biophysical and molecular biology methods, we work on the following projects, including (1) the change of biomechanical properties of blood cells, such as erythrocytes and dendritic cells; (2) the mechanical changes in blood tumor cells after transfection of tumor suppressor genes; (3) the mechanical changes of dendritic cells in tumor microenvironment; (4) the molecular basis for cell mechanics from the point of view of cytoskeletal proteins.

　　Hemorheology center is composed of one professor, four associate professors, and graduate students. We developed equipment for hemorheological study, including new eketacytometry, nuclear pore filtrator, double-direction rheometer, erythrocyte rheometer, and micropipette aspiration system. The new ektacytometry was named as the national-level new product in 1993 and awarded the third prize from Environment Ministry. The erythrocyte rheometer was approved for the national patent. Our research was awarded the third prize from Ministry of Education in 1999, and the second prize for Beijing Scientific and Technology Progress in 2000, and the third prize for Guizhou Scientific and Technology Progress in 2015. The graduate students were awarded many awards, including the Excellent Paper award in 2001, the Excellent Ph.D. Thesis award from Peking University in 2004, the Outstanding Student award and Wu-Si Scholarship in 2003, Wu-Si Medal from Peking University in 2006, and Chien-Fung award from International biorheology and hemorheology congress.   

　　Major findings: (1) We found that there were significant changes in the hemorheological properties in the development of red blood cells, and proposed a new animal model for synchronized erythrocyte development. (2) we studies the effects of tumor suppressor gens on the hemorheological properties of blood tumor cells and found that tumor suppressor genes could impair the deformation and migration of tumor cells by affecting cytoskeleton. (3) we found that there was significant changes in the development of dendritic cells, and that tumor microenvironment could cause the changes in the expressions of cytoskeletal proteins, which explain the reason for impaired hemorheological properties of dendritic cells and deteriorated immune functions. We have published over 100 SCI-indexed papers. Our results were cited and supported by journals such as blood, diabetes, Advances in Cancer Research, Arteriosclerosis Thrombosis and Vascular Biology, and Biophysical Journal, etc.

　　

　　Director: Yao wei-juan

　　Contact: Yao wei-juan

　　Email: weijuanyao@bjmu.edu.cn

　　TEL:82802419

　　Web：http://hemorheology.bjmu.edu.cn/