北京大学医学部神经影像研究中心成立于2015年，它是以大型科研设备GE Discovery MR 750磁共振扫描仪为核心组建的科研平台，为国内外研究者提供多方位的磁共振数据采集服务。同时，逐渐扩建围绕神经精神疾病的大样本数据库，进一步为推动脑成像研究发挥更好地基础支撑作用，提升医学部脑与脑疾病相关领域的研究水平。

　　研究方向一：与北京大学和美国LEIBER脑研究所合作，建立和完善多模态磁共振影像的脑结构和功能网络的计算理论与方法，开发可用于脑功能临床评估的成套神经心理学实验范式。

　　研究方向二：基于多模态神经影像技术，发现重大神经和精神疾病脑结构和功能网络的异常特征，获得用于早期诊断、预后评估以及疗效评价的影像学标志。

　　研究方向三：充分开展多学科交叉研究，发展现代生物技术、信息技术和成像技术为一体的创新脑科学方法。

　　北京大学医学部神经影像中心依托于北京大学第六医院，同时联合北京大学生命科学院、心理学系、物理学院及医学部多家附属医院等。中心成员汇集了神经影像学、生物学、临床神经和精神病学、分子遗传学等多个交叉领域内的研究专家，包括中国科学院院士2名、长江学者特聘教授3名、国家杰出青年6名。中心研究人员先后在国际刊物上发表了一批卓有贡献的研究论文，研究成果亦得到国际同行的广泛认可。中心具有的良好实验环境和先进仪器设备，购置的 MR750 (3.0T) 是目前国际上最先进的磁共振设备之一，能够保证采集图像的稳定性。此外，中心还配备了脑功能视听刺激系统、眼动追踪仪、E- Prime刺激编辑软件和MAC pro服务器等一整套用于脑功能研究的软件及硬件设施，很好的满足科研需求。

　　在前期的工作基础上，中心已建立了涵盖镇痛、成瘾、老年性痴呆、中风、精神分裂症、抑郁症和孤独症等疾病的大样本生物数据库，收集了丰富的临床资料、血样、DNA和影像数据；利用神经影像学方法，中心研究人员在神经科学、生物工程学、影像学、临床医学等领域取得了优秀成果，在Science、Nature、Nat Genet、Nat Neurosci、Neuron、PNAS等杂志发表论文。在脑信息处理方面发现条件性线索诱导的唤起-消退心理学范式能够消除信息在脑内的长期维持；慢波睡眠过程中条件性线索暴露可以消除情绪性记忆。神经影像学研究发现静息态人脑活动的局部和整合特征；应用脑影像计算理论与方法对精神分裂症患者进行早期诊断与筛查。影像学方法学研究开发了在细胞外空间进行神经纤维追踪技术。

    机构负责人：陆林

　　联系人：李鹏

　　邮箱：linlu@bjmu.edu.cn

　　电话：010-82805308

　　地址：北京市海淀区花园北路51号

　　Center for Neuroimaging of Peking University Health Science Center

　　Center for Neuroimaging of Peking University Health Science Center is founded in 2015, which is a scientific research platform that mainly includes large scientific research equipment such as magnetic resonance scanner (GE Discovery MR 750) and can provide extensive magnetic resonance data collection for researchers domestic and overseas. Meanwhile, through expanding the large sample database of neuropsychological diseases, we can put forward the research of brain imaging that plays a supporting role in brain science and promote the research level of brain and brain diseases of Peking University Health Science Center.

　　The first research orientation: We are going to cooperate with Peking University and LEIBER institute for brain research in order to found and perfect computing theory and methods of brain structure and functional network of multimode imaging data and develop a series of neuropsychological experiment paradigms for assessing brain function in clinic.

　　The second research orientation: On the basis of multimode neuroimaging technique, we can find abnormal characteristics of brain structure and functional network of serious neurological and psychotic disorders and obtain imaging mark for early diagnosis, prognosis evaluation and therapeutic evaluation.

　　The third research orientation: With the fully development of multidisciplinary intersection research, we can develop innovative brain science methods of modern biotechnology, information technology and imaging technology.

　　Center for Neuroimaging of Peking University Health Science Center is affiliated to Peking University Sixth Hospital. We cooperate with school of life sciences, Department of Psychology and School of Physics of Peking University and many affiliated hospitals of Peking University. Our center includes research experts major in neuroimaging, biology, clinical neurology and pathergasiology, molecular genetics and many crossing fields. There are two academicians of the Chinese Academy of Sciences, three Yangtze River Scholar Professors and six Distinguished Young Scholars of China. The researchers in our center published a series of contributive articles. The research achievements are widely accepted by international peers. There are favorable experimental environment and many advanced instrument and equipment. MR750 (3.0T) is one of the most advanced magnetic resonance equipment in the world, which guarantees the stability of imaging collection. In addition, our center is equipped with audio and visual stimulating system of brain function, eye tracker, E-Prime software and MAC pro server, which can be used for brain function study.

　　Important scientific achievements and contributions in recent years

　　On the basis of previous study, our center founded large sample biological database associated with many diseases such as analgesia, addiction, Alzheimer Disease, stroke, schizophrenia, depression and autism. We collected ample clinical materials, blood sample, DNA and imaging data. Through neuroimaging method, our researchers obtain excellent achievements in neurosciences, bioengineering, imaging, and clinical medicine and so on. We published many articles in Science, Nature, Nat Genet, Nat Neurosci, Neuron, and PNAS and so on. In brain information processing, we found that a novel UCS memory retrieval-extinction procedure can inhibit relapse to drug seeking and conditioned stimulus exposure in slow wave sleep can remove emotional memory. Neuroimaging studies found the regional and integrated characteristics of brain activities in resting state. We use computing theory and method of neuroimaging to diagnose and screen the patients with schizophrenia in the early stage. Imaging methodology is used to develop tracer technique of nerve fiber.

　　Chairman: Lin Lu

　　Contact: Peng Li

　　E-mail: linlu@bjmu.edu.cn

　　Phone: 010-82805308

　　Address: 51 Huayuanbei road, Haidian district, Beijing.