北京大学医学部女性盆底疾病研究中心于2017年12月成立，秉承“多学科协作研究女性盆底疾病发病机制，促进临床转化，提升盆底疾病诊治水平”，本虚体中心整合了北京大学多所临床医学院妇产科、泌尿外科、肛肠科、消化内科、整形外科、影像科、康复科及中医科知名专家，与北京大学前沿交叉学院、干细胞研究中心、磁共振研究中心、工学院生物力学与材料学的优秀科研人员通力协作，共同组建的盆底疾病交叉共融研究平台。

1.探究盆底疾病发病机制：研究盆底支持组织解剖和超微结构特征；建立盆底支持组织生物力学分析；研究力学敏感蛋白在盆底疾病中的意义和干预、自然衰老对盆底支持结构表观遗传学调控、肛提肌和会阴肌肉分娩损伤的多模态评估及修复机制、神经肌肉接头损伤在盆底肌萎缩中的意义。

2.构建盆底疾病病情评估体系：建立基于深度学习算法的MRI的盆底三维模型及有限元模型；借助影像学（高分辨超声在PFD中的应用、基于高分辨MR对会阴阴道周围肌群的评估、基于3D应力MR的智能化补片设计和盆腹动力学手段进行评估。

3.研发盆底修复新型材料与网片并发症发生机制：开发和优化丝素蛋白补片、补片修饰涂层技术；建立盆底疾病大动物模型，为临床转化奠定基础。

作为首席单位主持科技部“十四五”重点研发计划项目1项，主持“十三五”重点研发计划课题1项

在科研论著方面，科研成果已发表在Advanced Science、Frontiers in Endocrinology、American Journal Hematology、International Journal of Biological Science等高分SCI杂志上数十篇

获得中华医学科技奖一等奖1次，教育部科技奖二等奖1次，华夏科技进步奖、中华预防医学会科技进步奖、北京医学科技奖等其它省部级科技奖次

获得专利10余项，获得自主研发软件著作权5项，商标1项

搭建了老年尿失禁预防随访数据库及平台，组建了联合北大一院、北大深圳医院、北大国际医院、北京妇产医院、丰台妇幼保健院、房山妇幼保健院、武汉大学人民医院等18家医院的老年尿失禁预警预防随访平台数据库

连续20年举办北京大学女性盆底重建与生殖整复研讨会（国际会），累计注册学员上万人，宣传并培训国内本专业专科医师上千人

机构负责人：王建六

联系人：冯艺帆

邮箱：fffinezz@outlook.com

电话：010-88324384,18330100480

地址：北京市西城区西直门南大街11号

网址链接：http://pelvisology.cogonline.com.cn/

Peking University Health Science Center Female Pelvic Floor Research Institute (PKUHSC FPFRI)

The Female Pelvic Floor Disorders Research Center of Peking University Health Science Center (PKUHSC FPFRI), established in November 2017, is committed to advancing the understanding of female pelvic floor disorders through multidisciplinary collaboration, with a mission to "investigate the pathogenesis of pelvic floor diseases via interdisciplinary approaches, facilitate clinical translation, and elevate the standards of diagnosis and treatment." This university-level platform integrates renowned clinical experts from multiple departments across Peking University's affiliated hospitals, including Obstetrics And Gynecology, Urology, Colorectal Surgery, Gastroenterology, Plastic Surgery, Radiology, Rehabilitation Medicine, and Traditional Chinese Medicine. It synergizes with leading researchers from the Peking University Academy for Advanced Interdisciplinary Studies, Stem Cell Research Center, Magnetic Resonance Imaging Research Center, and the Biomechanics and Materials Science Division of the College of Engineering, forming a cross-disciplinary research hub dedicated to pelvic floor disorders.

1. Investigating Pathogenesis of Pelvic Floor Disorders

Mechanistic Studies: Elucidate the anatomical and ultrastructural characteristics of pelvic floor supportive tissues.

Biomechanical Modeling: Establish biomechanical analysis frameworks for pelvic floor support systems.

Molecular Pathways: Investigate the role of mechanosensitive proteins in disease progression and therapeutic interventions.

Aging & Epigenetics: Explore age-related epigenetic regulation of pelvic floor supportive structures.

Childbirth Injury: Conduct multimodal assessment of levator ani and perineal muscle injuries during childbirth, alongside mechanistic studies on tissue repair.

Neuromuscular Dysfunction: Decipher the impact of neuromuscular junction damage on pelvic muscle atrophy.

2. Developing Pelvic Floor Disease Assessment Systems

AI-Driven Modeling: Construct 3D pelvic floor models and finite element models using MRI data integrated with deep learning algorithms.

Advanced Imaging:

Optimize high-resolution ultrasound for pelvic floor dysfunction (PFD) diagnosis.

Implement high-resolution MRI for precise evaluation of perineal and vaginal muscle groups.

Develop 3D stress MRI for intelligent mesh design and dynamic assessment of pelvic-abdominal biomechanics.

3. Innovating Biomaterials & Addressing Mesh Complications

Material Engineering: Design and refine silk fibroin-based mesh with advanced surface modification technologies.

Preclinical Models: Establish large animal models of pelvic floor disorders to validate therapeutic strategies and accelerate clinical translation.

Complication Mechanisms: Investigate the pathophysiology of mesh-related complications to guide safer surgical interventions.

Director: Jianliu Wang

Contact: Yifan Feng

Email: fffinezz@outlook.com

TEL: 010-88324384, +86 18330100480

Address: No.11 Xizhimen South Street, Xicheng District, Beijing, P.R.China

Website：http://pelvisology.cogonline.com.cn/