1982年童坦君教授和张宗玉教授建立衰老分子机理研究室，2004年3月以该研究室为主体正式成立北京大学衰老研究中心。中心由北京大学下属8个单位组成，研究领域涉及衰老的分子机理研究、老年常见病发病机理、老年生物学、老年人口学等方面，力求通过多学科交叉融合，共同探索人类衰老这一现代医学前沿课题。陈可冀院士担任中心学术委员会主任委员，童坦君院士担任中心主任。

衰老分子机理-----衰老相关基因及其调控网络。包括p16、CSIG等细胞衰老关键基因的表达调控研究、衰老相关分泌表型研究、环境与基因影响衰老连接点研究、非编码RNA在细胞衰老中的作用研究、肿瘤与衰老研究等。

    北京大学衰老研究中心是国内从事衰老分子机理研究最早的实验室之一，近年在国家多项科研基金的资助下，课题组在科室建设、人员配备和学术交流等方面均有了很大程度的发展。中心拥有具有衰老基础研究特色的细胞、质粒、基因等生物资源和常规细胞生物学和分子生物学技术平台，作为依托单位的北京大学医学部生化系还可以提供激光共聚焦显微镜、流式细胞仪、实时定量PCR仪等大型共享设备。在童坦君院士的带领下，衰老研究中心建立了包括教授、副教授、讲师、博士后和研究生的学术梯队，为衰老基础研究领域培养了大批专业人才。中心先后承担科技部“973”课题、国家自然科学基金重点项目和面上项目、985课题、教育部博士点专项基金等多项研究课题，科研成果荣获国家级奖励1项、省部级奖励20余项。

衰老研究中心主要科研成果包括：建立了一套国际承认的评估细胞衰老的定量指标；系统揭示了p16，SirT1等细胞衰老相关基因的表达调控机制；进行了CSIG等多个衰老相关新基因的克隆和功能研究；在衰老相关分泌表型（SASP）、RNA与衰老、肿瘤与衰老等各项研究中取得了重要突破。中心成立以来，衰老基础医学研究团队不断壮大，技术平台日渐完善，中心已累计发表科研论文百余篇，编写出版了《医学老年学》等教材以及面向大众的科普读物。

 

机构负责人：童坦君

联系人：李国栋

邮箱：liguodong1977@bjmu.edu.cn

电话：010-82801454

地址：北京大学医学部生化楼227室

网址链接：http://age.bjmu.edu.cn（仅限校内）

 

 

Peking University Research Center on Aging

In March 2004, Peking University Research Center on Aging was formally established, based on theMolecular Mechanism Laboratory on Aging which was founded by Professor TanjunTong and Professor Zongyu Zhang in 1982. Comprised of eight subordinate units of Peking University, the research center aimed to explore the frontiers of modern aging medicine through multi-disciplinary integration, such as molecular mechanism of aging, pathogenesis of senile diseases, geriatric biology and geriatric demography. Chinese academician Keji Chen served as the chairman of the academic committee and academician Tanjun Tong was the director of the research center.

Research Direction

Molecular mechanism of aging- aging related genes and their regulation network. Including expression and regulation of p16, CSIG，SirT family and other key genes in cell senescence, senescence-associated secretory phenotype, environmental and genetic impact on senescence, the role of non-coding RNA in cell senescence, tumor and aging, etc

 

Peking University Research Center on Aging is one of the earliest laboratories for aging molecular mechanism researchin China.In recent years, the research group has made great progress in laboratory construction, professional staffing and academic exchanges. Besides of the platform of conventional cellular and molecular biology research, the center has accumulated abundant resources related to aging research such as cells, plasmids and genes. In addition, Department of Biochemistry  and Molecular Biology in Peking University Health Science Center could provide sharing large-scale instruments, including confocal microscopy, flow cytometry, real time quantitative PCR. Under the guidance of academician Tanjun Tong, the center has established academic echelons including professors, associate professors, lecturers, post-doctors and postgraduates, and has trained a large number of professionals for aging basic research. To date, the center has undertaken many research projects such as the National Basic Research Program of China project, the key projects and the general projects of National Natural Science Foundation and the national “985” projects. The research group has gained one national award and more than 20 provincial and ministerial awards.   

The main achievementsof Peking University Research Center on Aging include: establishing a set of quantitative indexes for cell senescence evaluation; revealing the expression and regulation mechanism of p16, SIRT1 and other senescence related genes; cloning and functional analysis of CSIG and other novel senescence associated genes; making a breakthrough in the study of senescence-associated secretory phenotype (SASP), RNA and senescence, tumor and senescence. In recent years, the research team of basic aging medicine in our center is growing and the technology platform is significantly improved. More than one hundred research papers have been published. The center published the "Medical Gerontology" and public oriented brochures and established the postgraduate course of "Biochemistry and Molecular Biology of Aging".

 

Director: Tanjun Tong

Contact: Guodong Li

Email: liguodong1977@bjmu.edu.cn

TEL: 010-82801454

Address: Department of Biochemitry Building, Room 227, Peking University Health Science Center

Website：http://age.bjmu.edu.cn（Intranet）