北京大学中国药物依赖性研究所创建于1984年，由卫生部批准在北京大学医学部建立“药物依赖性研究中心”。1988年，“药物依赖性研究中心”正式改建为“北京大学中国药物依赖性研究所”。近30年来，研究所逐步发展成为集药物依赖性基础研究、临床研究、药物滥用流行病学研究、药物滥用监测、药物依赖性信息研究以及编辑出版药物依赖性杂志和相关书刊、组织学术会议等职能为一体，同时还是教育部精神病与精神卫生学、神经生物学和药理学国家重点学科的主要参与单位，国家禁毒委中国毒品滥用防治专家委员会秘书处、中国药物依赖性专业委员会秘书处也设立在本所。

　　研究所由以下研究室组成，涵盖药物成瘾及相关疾病的基础、临床和流行病学研究。

　　神经药理学室——主要进行精神活性物质以及成瘾性药物脱毒治疗的相关临床前研究

　　临床药理学室——开展新型治疗药物及方法的临床研究，以治疗药物依赖为战略目标

　　毒品检测室——进行生物样品中滥用药物的检测、滥用药物快速检测的标准建立以及明确人体药物代谢和生物转化对药物成瘾和复吸的影响

　　药物流行病学研究室——进行药物滥用流行病学调查以及国家监测

　　药物依赖信息研究室——获取、研究以及整合中国和其他国家的药物依赖和药物滥用信息

　　药物依赖性研究重点实验室——从事药物滥用的潜在神经生物学机制及可能的治疗方法研究，以及药物成瘾的流行病学和社会学，涵盖了基础、临床以及社会学研究

　　新药研发与评价室——通过临床前研究探索药物成瘾及其他精神疾病的合格候选药物

　　在禁毒领域，研究所以药物依赖性研究北京市重点实验室作为专业平台，在由中国科学院院士、长江学者、国家杰出青年和国家自然科学基金委创新研究群体组成的优秀研究团队带领下，在科技部、国家自然科学基金委、国家禁毒办、卫生计生委、教育部和北京市等资助的十三五重点研发计划、973、863、重大新药创制、传染病防治科技重大专项和重大研究计划等数十项基金及多项国际合作项目的支持下，深入研究药物滥用与成瘾的分子生物学机制，为其治疗提供新的候选干预靶点；同时将研究成果应用于临床实践，开发新的药理学和心理学治疗措施；并通过流行病学、卫生统计学、循证医学和时空数学模型等研究方法和手段，阐明我国物质滥用及相关疾病的流行现状、影响因素、流行趋势，从而制定有效的干预和预防策略。在药物成瘾的基础、临床和流行病学研究等方向取得了一系列重要原创性成果，发表研究论文近500篇，其中250余篇发表在SCI期刊，包括Science、Lancet、Neuron、American Journal of Psychiatry、Nature Communications等国际知名期刊，获得授权专利9项，研究成果多次获得教育部高等学校科学研究优秀成果奖（自然科学奖）一等奖、中华医学科技奖二等奖、北京市科学技术进步奖二等奖等学术奖励，在药物成瘾及相关疾病的研究领域具有重要的国际学术影响力。     

　　研究所近年来在病理性记忆的分子基础和消除策略研究领域取得了一系列突破性进展：发现泛素化依赖的蛋白降解和eIF2α调控的蛋白翻译过程是记忆去稳定和再稳定的必要条件，胶质细胞和神经元间的乳酸转运以及神经元内的多个激酶（如PKMζ、cdk5、GSK 3β等）通路的活化是病理性记忆维持的分子基础，而神经元周围基质网在病理性记忆消除过程中发挥着关键的调控作用。这一系列成果解释了病理性记忆在脑内长期存在的生物学基础，发展了精神疾病的病理性记忆理论，为药物成瘾等病理性记忆相关精神疾病的临床治疗提供了理论支持和潜在的干预靶点。在此基础上，首次提出可有效消除病理性成瘾记忆的“条件性刺激唤起-消退”心理学范式和“非条件性刺激唤起”模式，并创新性提出通过在睡眠中暴露记忆相关线索从而无痛苦地消除负性情绪反应的新方法，相关研究发表在Science、JAMA Psychiatry、Biol Psychiatry等杂志上，获得国际同行的多次专题评价和广泛引用验证“为源于病理性记忆的精神疾病和行为障碍的治疗开辟了全新的视角”。

　　

　　机构负责人：时杰

　　联系人：吴萍

　　邮箱：wuping@bjmu.edu.cn

　　电话：13426455876

　　地址：北京市海淀区学院路38号两所楼

　　

　　

　　

　　National Institute on Drug Dependence

　　National Institute on Drug Dependence (NIDD), established in the year of 1984, is a state-level research institute approved by the State Council of China, engaging in research on drug dependence.  NIDD, affiliated to Peking University, is under the jurisdiction of National Narcotics Control Commission, Ministry of Health, and State Food and Drug Administration of China in vocational work.

　　NIDD was composed of the following departments:

　　Department of Neuropharmacology：Preclinical studies on psychoactive substances and drugs for detoxification

　　Department of Clinical Pharmacology：Clinical studies for new drugs and therapies

　　Department of Drug Testing：Testing abused drugs in biological samples, establishing standard protocols for quick detection of abused drugs

　　Department of Drug Epidemiology：Epidemiological survey of drug abuse and national surveillance on drug abuse Studies on underlying neurobiological mechanisms and possible solutions of drug abuse, as well as the epidemiology and sociology in addiction field

　　Department of Information on Drug Dependence：To acquire, study and integrate information on drug dependence and drug abuse from China and other countries

　　Key Laboratory of Drug Abuse and Addiction：To discover the eligible candidate medication for drug addiction and other psychiatric disorders through preclinical investigation

 

　　

In the field of drug control, based on the Key Laboratory on Drug Dependence Beijing, led by academician of Chinese Academy of Sciences, Changjiang Scholar, Outstanding Young Investigators and Innovative Research Groups of the National Natural Science Foundation of China, funded by Ministry of Science and Technology, National Natural Science Foundation of China, Office of China National Narcotics Control Commission, National Health and Family Planning Commission, Ministry of Education and Beijing government, the institute engages in research on molecular biological mechanisms of drug abuse and addiction and development of novel intervention target; applies the research findings in clinical practice, and develop novel pharmacological and psychological intervention methods; based on epidemiology, health statistics, evidence-based medicine and spatio-temporal mathematical models, we will clarify the current situation, influencing factors and epidemic trend of substance abuse and related diseases in China, so as to formulate effective intervention and prevention strategies. A series of important original achievements have been achieved in the basic, clinical and epidemiological studies of drug addiction, almost 500 papers have been published, 250 of which were published on SCI journals including Science, Lancet, Neuron, American Journal of Psychiatry, Nature Communications, and 9 patents have been approved. First prize of Science Research Famous Achievement Award in Higher Institution (Natural Science Award), second prize of China Medical Science and Technology Award, second prize of Prize for Progress in Science and Technology, etc. have been awarded. The institute has produced important international academic influence in the field of drug addiction and related diseases

 

　　The institute has achieved a series of breakthroughs in the field of molecular basis and erasure methods of pathologic memories: revealed the trajectories and molecular mechanisms of drug craving: They discovered the incubation phenomenon of opioid craving, and revealed the roles of pathways such as ERK-CREB in incubation and relapse; found the alterations in cognition and circadian rhythm after abstinence: The impairment in decision making recovers with time of abstinence, but can be exacerbated by exposure to stress or heroin-related contextual stimulus, and disorder in the expression of clock genes and related molecules is an important inducer of long-lasting craving and relapse; explained why pathological memories persist for long periods of time and are extremely difficult to be erased, and developed a novel non-pharmacological approach to erase pathological memories: PKMζ is required for the storage of drug memory, and eIF2α dephosphorylation in basolateral amygdala mediates reconsolidation of drug memory. Based on these, the achievers for the first time raised that the “conditioned stimulus memory retrieval-extinction” procedure could erase drug memory, and developed a novel method to erase negative emotional responses painless during sleep. These findings have been published on journals including Science, JAMA Psychiatry, Biol Psychiatry, and have been commented and cited by many researchers around the world, and opened up novel perspectives for treatment of psychiatric diseases and behavioral disorders originated from pathological memories.

　　

 

　　Person in charge：Shi Jie

　　Contacts：Wu Ping

　　E-mail：wuping@bjmu.edu.cn

　　Tel：13426455876

　　ADD：280 mailbox, 38 Xueyuan Road, Haidian District,Beijing,100191