北京大学医学同位素研究中心隶属于北京大学（医学部），成立于2001年。医学同位素中心一贯以创新型科研和人才培养为目标，凭借北京大学医学部百余年所积淀的深厚的医学和生物学研究基础，通过多学科交流与融合，结合中心自身的条件，在核医学分子影像及同位素示踪技术应用领域开展了系统的研究工作。经过十余年的建设，已建成一个完整的从分子、细胞水平到组织水平再到活体动物和临床转化的分子影像探针及放射性药物的制备和评价平台。

　　近年来，同位素研究中心在教育部、科技部和国家自然科学基金委等单位的资助下，开展了一系列具有特色的研究工作。研究工作主要包括以下方面：

　　- 放射性药物转化医学研究

　　- 新型肿瘤特异性分子探针

　　- 肿瘤治疗疗效监控

　　- 肿瘤放射靶向治疗

　　- 多功能分子探针

　　目前，同位素研究中心有教职工7名，其中教授2名，副研究员3名，副主任技师1名，工程师1名。在读博士和硕士研究生共19人。研究中心依靠上述平台开展了一系列独具特色的研究工作，先后主持承担国家“十五”科技攻关项目，“863”项目，国家“重大新药创制”重大科技专项课题，国家自然科学基金委青年基金、面上项目、重点项目、重点国际合作项目、优秀青年科学基金、国家杰出青年科学基金等。获授权的国家发明专利8项。2008年获美国核医学学会Berson-Yalow奖。

　　针对靶向integrin αvβ3的RGD多肽分子探针进行了深入系统的基础研究，完成了从小动物显像到大动物显像再到临床应用的过渡，发表了一系列研究论文，研制出新型特异性肿瘤显像剂^99mTc-3PRGD2，并获得国家发明专利，并成功进行了成果转化。临床研究证实了^99mTc-3PRGD2的安全性和有效性，目前已启动新药申报，获得了受理号。研制的显像剂^99mTc-3PRGD2其临床价值在于进行肿瘤的筛查、肿瘤的早期诊断、肿瘤的在体分子分型、肿瘤的分期和预后、肿瘤治疗的疗效监测以及指导个体化治疗，其科学价值在于解决了通过SPECT显像进行多种肿瘤检测的技术瓶颈问题。

　　

　　机构负责人：王凡

　　联系人：赵慧云

　　邮箱：zhhy@bjmu.edu.cn

　　电话：010-82802871

　　地址：北京市海淀区学院路38号北京大学医学部中心实验楼3层

　　网址链接：http://www.medisotope.com/

　　

　　

　　Medical Isotopes Research Center, Peking University

 

　　Medical Isotopes Research Center, Peking University (Health Science Center), was established in 2001. Innovative research and personnel training has always been the goals for Medical Isotope Research Center. With Peking University Health Science Center for more than a hundred years of high-quality medical and biological research base, through multidisciplinary exchange and integration, combined with the center's own conditions, our center conducted systematic researches on nuclear medicine molecular imaging and isotope tracing technology. After more than 10 years of construction, a complete platform for the preparation and evaluation of molecular imaging probes and radiopharmaceuticals from molecular level, cellular level to tissue level, as well as to live animal and clinical translation has been established.

 

　　In the recent years, Medical Isotope Research Center has carried out a series of research under the support of the Ministry of Education, the Ministry of Science and Technology and the National Nature Science Foundation of China. Our research mainly includes the following aspects:

　　Translational research of radiopharmaceuticals

　　Novel tumor targeting molecular probes

　　Tumor therapeutic response monitor

　　Tumor targeting radiotherapy

　　Multi-functional nanoprobe

　　Currently, Medical Isotopes Research Center contains 7 faculty members, including 2 Professors, 3 Associate Professors, 1 Associate Director Technician and 1 Senior Engineer, and a total of 19 doctoral students and master students. Relying on the above research platform, the members in the lab are actively exploring a series of unique research tasks. The lab has participated in National Key Technology Research and Development Program, “863” projects, Key Science and Technology Project for “Innovative New Drugs”, NSFC General Programs, Key Programs, Key international cooperation projects, Outstanding Youth Science Foundation, National Science Fund for Distinguished Young Scholars. In addition, the lab has received 8 China National Invention Patents. Relevant achievements have won Berson-Yalow Award granted by Society of Nuclear Medicine and Molecular Imaging.

　　Medical Isotopes Research Center have conducted a systematic and fundamental research on integrin αvβ3-targeted probe RGD peptide, and completed the translation from small animal imaging to large animal imaging and then to clinical application. We published a series of research papers on the development of the novel tumor-specific imaging agent ^99mTc-3PRGD2, got several related patents, and have successfully translated it into the clinical practice. Clinical studies have confirmed the safety and effectiveness of^99mTc-3PRGD2 and we are now applying for the approval of CFDA for its routine clinical use. The clinical applications of ^99mTc-3PRGD2 will focus on screening and early detection of tumors, molecular classification in vivo, staging, treatment monitoring, and prognosis evaluation towards personalized medicine. The scientific value is to solve the technical bottleneck problem of multiple tumor detection by SPECT imaging.

　　

　　Laboratory Director：Fan Wang

　　Contact Person: Huiyun Zhao E-mail：zhaohy@bjmu.edu.cn

　　Tel：010-82802871

　　Address：38 Xueyuan Road, Haidian District, Beijing

　　Web link：http://www.medisotope.com/