2014年10月23日，北京大学第六医院被科技部、国家卫生和计划生育委员会和总后勤部卫生部正式认定为国家精神心理疾病临床医学研究中心。中心由北京大学第六医院牵头并联合北京大学心理与认知科学学院、北京大学中国药物依赖性研究所等共建单位共同组建。中心充分利用协同研究网络的医疗资源优势，开展切合疾病内在预防诊治规律的原创性研究，探索符合国情的精神疾病预防诊治措施与技术。目前，中心已有超过100家网络成员单位。

　　本中心针对精神科常见情感认知障碍，包括抑郁障碍(MDD)、精神分裂症(SCH)、注意缺陷多动障碍(ADHD)、睡眠-觉醒障碍、老年痴呆等，开展多中心大样本队列研究，建立了符合国际规范的“基因-神经心理-神经生理-临床表型”数据库及标准化生物样本库。通过多学科、多维度、多模态组学研究，构建早期客观识别体系及诊断预测模型。中心统筹全国网络成员单位开展规范化临床研究，为患者提供精神心理疾病网络注册登记、规范化评估及疾病的研究型诊疗服务。对参与单位骨干人员开展精神障碍规范化评估、诊断与干预工具培训、研究型诊疗服务的普及和推广、质量控制和研究能力培训，大力提升了整体研究能力。

　　中心目前已组建了以院士、国家百千万人才、“973”计划及基金委创新群体首席科学家、长江学者计划特聘教授、国家杰出青年及优秀青年科学基金获得者、教育部新世纪优秀人才、博士生导师为学术带头人，中国科协青年托举工程人才、北京市科技新星、北京市“十百千”优秀卫生人才等科研人员为骨干的年龄结构合理、创新能力强的临床研究梯队。

　　中心在生物精神病学、社会精神病学、儿童精神病学、临床精神病学、身心医学和神经精神药理学等领域拥有优秀的临床研究团队。建立了精神疾病生物标记物评价平台、脑电监测系统以及病理性记忆动物模型研究平台等研究平台，牵头承担了多项国家重点研发计划、国家自然科学基金创新群体及重点项目等国家级重大课题，在JAMA Psychiatry、Molecular Psychiatry、Biol Psychiatry、Lancet Psychiatry等重要期刊上发表了系列文章，受到国际同行的高度评价和广泛引用，在国际上产生重要学术影响。研究团队获得了教育部科学技术进步奖、北京市科学技术奖、中华医学科技奖、华夏医学科技奖等多项奖励。2015-2017连续三年获得中国科技影响力排行榜精神病学学科第一，北京大学精神病学/心理学进入全球基本科学指标数据库(ESI)前1%，成为国际高水平学科之一。

　　中心开展了系列精神心理疾病应用基础研究，在国际上产生了重要的学术影响。首次在国际上报道唤起-消退模式可以消除病理性记忆，为成瘾及其他疾病的治疗提供了新的方向。中国汉族人群精神分裂症、注意缺陷多动障碍、抑郁症、孤独症等易感基因及脑影像学特征研究取得丰硕成果，如首次报道中国汉族人群精神分裂症易感基因并深入探索新型易感基因的潜在功能，采用影像遗传学手段发现注意缺陷多动障碍受遗传因素影响的脑影像学特征与药物疗效显著关联。为我国精神心理疾病防治工作做出突出贡献，完成了首次具有全国代表性的精神障碍流行病学调查，初步明确了我国精神心理疾病概况及卫生服务利用情况，为国家制定精神卫生政策提供了依据。

　　机构负责人：陆林

　　联系人：王雪萍

　　邮箱：liuyuankeban@163.com

　　电话：82801944

　　地址：北京市海淀区花园北路51号

　　网址链接：http://www.pkuh6.cn/Html/News/Main/277.html

　　

　　National Clinical Research Center for Mental Disorders (Peking University Sixth Hospital)

　　On October 23th, 2014, Peking University Sixth Hospital was identified as the National Clinical Research Center for Mental Disorder by the Ministry of Science and Technology, National Health and Family Planning Commission, and Medical Department of General Logistics Department. The center was initiated by the Peking University Sixth Hospital and jointly constructed by School of Psychological and Cognitive Sciences, National Institute on Drug Dependence (Peking University), and other participating institutes.We are trying to make full advantage of medical resources, to carry out the original research on the diagnosis, to explore the prevention and treatment measures. More than 100 collaborative research members across China have joined in the National Clinical Research Center.

　　The center intended to conduct standard cohort studies for common affective-cognitive disorders, including major depressive disorder (MDD), schizophrenia (SCH), attention deficit hyperactivity disorder (ADHD), sleep-wake disorders, dementia and so on. We established "gene-neuropsychological-physiological-clinical phenotype" databases and biobanks complying with international standards. Through multidisciplinary, multi-dimensional and multi-modal studies, the early objective recognition system and diagnostic predictive models have been constructed. Institutes of National Clinical Research Center are coordinated to carry out standardized clinical research, including standardized assessment and treatment services. Combining strict quality control and research training, we are devoting ourselves to improve the national psychiatric research capacity.

　　The center established a clinical research echelon with reasonable age structure and strong innovation ability which includes the Academicians, the National Millions Talent, the chief scientist of Foundation for Innovative Research Groups of the National Natural Science Foundation of China and the State Key Development Program for Basic Research of China (973 program), the Yangtze River Scholars Distinguished Professor, Winners of National Natural Science Foundation of China for Distinguished Young Scholars and National Natural Science Foundation of China for Outstanding Young Scholars, the New Century Excellent Talents in University and Ph.D. supervisors as the academic leaders, and the Supported Young Talent by China Association for Science and Technology, the winner of the Science and Technology Nova Plan and Beijing ten hundred thousand excellent health professionals as key members.

　　The center has excellent clinical research teams in the field of biological psychiatry, social psychiatry, child psychiatry, clinical psychiatry, psychosomatic medicine and neuropsychopharmacology. We established evaluation platform to identify mental disease biomarkers, EEG monitoring systems and research platform for the pathological memory animal models, etc. The members take the lead to charge multiple items of national major projects including National Key Research and Development Program, and the Foundation for Innovative Research Groups of the National Natural Science Foundation of China, etc. The members have published a series of research articles in many famous journals including JAMA Psychiatry, Molecular Psychiatry, Biol Psychiatry, Lancet Psychiatry, Nature communication, Journal of Neuroscience, etc. These published papers had gained many special comments and extensive repetition and citations from international counterparts, which generated important academic influences in the worldwide. The research team won many awards, such as the science and technology progress award of the Ministry of Education, the Beijing Prize for Science and Technology, the Chinese Medical Science and Technology Award, the Chinese Medical Science and Technology Award, and so on. During the three consecutive years from 2015 to 2017, the center won the first position of China's science and technology influence list of psychiatry, and the Psychiatry / Psychology of Peking University has entered the TOP 1% of the global basic scientific index database (ESI), which suggested that the Psychiatry / Psychology had become one of the international high-level disciplines.

　　The research team of our center has performed a series of applied basic researches on mental and psychological diseases, which has an important academic influence in the worldwide. The studies on diseases achieved fruitful results, such as schizophrenia, attention deficit hyperactivity disorder (ADHD), major depressive disorder, autism, sleep and addiction. For example, the members first reported the elimination of pathological memory by evocation-extinction patterns providing a new direction for the treatment of addiction and other diseases. Researchers have reported novel susceptibility genes of schizophrenia in Chinese Han population and further explored the potential function of these new susceptibility genes. Another research team has found the significant association between drug efficacy and brain imaging characteristics affected by genetic factors in ADHD. In addition, the social psychiatry research team completed the China Mental Health Survey (CMHS), which is the first nationally representative community survey on mental disorders and mental health services in China. They further analyzed the influence factors in the mental health services utilization using the CMHS database. These results will be helpful to find the solutions for the effective use of mental health services and formulate the relevant policies.

Derector: LU Lin

Contact: WANG Xueping

Email: liuyuankeban@163.com

TEL：82801944

Website: http://www.pkuh6.cn/Html/News/Main/277.html