北京大学口腔医院国家口腔疾病临床医学研究中心是科技部会同国家卫生计生委、军委后勤保障部和食品药品监管总局2016年认定的国家临床医学研究中心。成立一年多以来，中心针对临床研究瓶颈问题，将回顾性研究与前瞻性研究整合，开拓临床研究创新体系，建立以多目标多任务研究方案为基础的新型临床研究模式；构建规范化、高质量的协同研究网络和多中心研究平台，开展多中心、大规模、高质量的口腔疾病临床队列研究，提升全国口腔疾病预防、诊断、治疗和康复的综合服务水平，切实解决临床关键问题，提高国民健康水平。

　　中心以影响口腔健康最为严重的口腔颌面部肿瘤、涎腺疾病、牙颌面畸形、龋病、牙周病、牙齿缺损/缺失等疾病为主要临床研究领域，以北京大学口腔医院相关疾病领域的研究团队为核心，协同核心研究网络的成员单位，进行国家层面高质量的全国多中心临床研究。具体包括：

　　（1）龋病、牙周病一体化溯源预防、早期干预、三级防控临床研究；

　　（2）口腔颌面功能修复临床研究；

　　（3）牙颌面畸形多学科综合序列治疗规范的建立、关键技术的创新与临床推广应用研究；

　　（4）口腔颌面-头颈肿瘤诊治规范的建立及实施；

　　（5）涎腺疾病系统性、微创性、规范化诊疗临床研究；

　　（6）口腔精准医疗临床研究。

　　北京大学口腔医院以顶尖的临床服务和精湛的医疗技术享誉国内外，始终以建设研究型医院为目标，以“防治口腔疾病、促进人民口腔健康”为己任，积累了雄厚的科研基础和临床技术实力。近十年来医院先后承担国家973计划、863计划和科技支撑计划课题等国家重大科研项目课题28项，承担卫生计生委、教育部、北京市科委、国家自然科学基金和国际组织合作研究项目258项，总研究经费逾3.3亿元。获得国家科技进步二等奖1项、省部级奖项16项。近十年来发表学术论文3500余篇，SCI论文655篇，主编出版了有重要影响的临床学术专著百余部，在全国口腔医学临床科研和基础科研领域具有重要的影响力。

　　以全面提高口腔疾病的防治水平和促进临床转化应用为总体目标，联合了37家分中心单位，创建了具有国际影响力、辐射全国的口腔疾病诊治及临床研究协同创新网络，紧密围绕我国口腔疾病防、诊、治的重大需求和临床重大问题，提出战略分析，通过顶层设计确定战略性研究方向，设计、组织、实施协同攻关研究，研发有中国特色的口腔疾病防、诊、治技术体系，并制定诊疗规范与指南。发挥辐射引领作用，显著提高我国口腔疾病临床防治与转化研究的整体水平。国家中心将适应口腔疾病和临床研究不断发展的需要，充分整合国家和区域临床医学研究资源和研究力量，发挥中心引领、网络协同的优势，不断创新方法与机制，瞄准国内外临床研究的热点、难点和前沿领域，力争在口腔疾病研究中取得重大突破，从而推动口腔疾病临床医学发展。

　　

　　机构负责人：郭传瑸

　　联系人：徐明明

　　邮箱：anniemmx@126.com  

　　电话：01082195710

　　地址：北京市海淀区中关村南大街22号

　　

　　

　　National Clinical Research Center for Oral Diseases

　　

　　Peking University Stomatological Hospital National Clinical Research Center for Oral Diseases is a national clinical research center identified by the Ministry of Science and Technology in conjunction with the National Health and Family Planning Commission, CPC Central Military Commission Logistics Support Department and General Administration of Food and Drug Administration in 2016. Since it was established, the center has been integrating retrospective study with perspective study to work on bottleneck problems, develop clinical research and innovation systems, set up a new model of clinical research on multi-objective and multi-task program based on collaborative research network; construct a standardized and high-quality collaborative research network and multi center research platform to carry out multi center, large scale and high quality researches on clinical cohort study of oral diseases, comprehensively service to enhance the level of national oral disease prevention, diagnosis, treatment and rehabilitation, and effectively solve the key clinical problems and improve the national health level.

　　The center regards oral and maxillofacial tumors, salivary gland disease, severe maxillofacial deformities, dental caries, periodontal disease, tooth defect & lack and other seriously affecting oral health diseases as main clinical research fields, takes the research team in Peking University Stomatological Hospital of related diseases as the core, cooperates with the research network member units and conducts the national multi center clinical research on the national level. Specifically, it includes:

　　(1) The prevention, early intervention, and tertiary prevention of caries and periodontitis.

　　(2) Oral and maxillofacial function repair;

　　(3) The establishment of the multidisciplinary integrated sequential therapy for dental and maxillofacial malformation, the innovation of key technology and the application of clinical application.

　　(4) The establishment and implementation of oral and maxillofacial - head and neck tumors diagnosis and treatment.

　　(5) Systematic, minimally invasive, standardized CR of salivary gland disease;

　　(6) Oral precision medical treatment.

　　Peking University Stomatological Hospital enjoys high reputation at home and abroad for its top clinical service and superb medical technology, which has always been regarding the construction of research-oriented hospital as the goal, striving to achieve "prevent oral diseases and promote people's oral health" as its responsibility. It has accumulated a solid foundation of scientific research and clinical technical strength. In recent ten years, the hospital has assumed the national 973 Plan, 863 Plan and Technology Support Program and other 28 major national research projects, 258 programs from Health and Family Planning Commission, the Ministry of Education, Beijing Municipal Science and Technology Commission, National Natural Science Foundation of China, etc, with a total of 330 million yuan of funds. The hospital also has won the second prize of National Science and Technology Progress Award once, and 16 provincial and ministerial awards. Over the past ten years, more than 3500 academic papers have been published, including SCI 655 papers, over 100 clinical academic monographs were published as a chief editor, which has important influence in the field of clinical research of stomatology in China.

　　In order to comprehensively improve the level of prevention and treatment of oral diseases and clinical transformation, the hospital unites 37 branch centers to create a national collaborative innovation network of oral disease diagnosis and treatment with international influence and national radiation, focusing on the prevention, diagnosis and treatment of the major clinical needs and problems, which puts forward strategic analysis to determine the strategic research direction via top-level design. It designed, organized and implemented collaborative researches to develop an oral disease prevention, diagnosis and treatment system with Chinese characteristics, formulates the diagnosis standards and guidelines. The overall level of research on the clinical prevention and treatment of oral diseases in China was therefore significantly improved by giving full play to the leading role of radiation. The National Center will adapt to the development of oral diseases and clinical researches, conduct a full integration of national and regional medical research resources and strengths, play a leading and collaborative advantage, constantly innovate approaches and mechanisms aiming at home and abroad clinical research focuses and frontier areas, and strive to achieve a major breakthrough in the study of oral diseases so as to promote the growth of clinical medicine of oral diseases.

　　

　　Director：Guo Chuan-bin

　　Contact：Xu min-min

　　E-mail：anniemmx@126.com

　　Phone：01082195710