本实验室依托单位为北京大学，其前身是成立于1984年的卫生部心肺内分泌调节肽重点实验室，1994年更名为心血管分子生物学和调节肽卫生部重点实验室,是我国第一个心血管重点实验室，并于2002年成立为分子心血管学教育部重点实验室，本实验室是国内心血管领域里研究心血管活性多肽、肾上腺素受体、代谢性核受体和心血管分子生物学历史最为悠久，影响最大的实验室之一，其中主要PI构成的基金委代谢性心血管病创新群体已获得两次连续资助，已成为我国从事心血管代谢性疾病基础研究的主要基地。实验室于2005年、2010年及2016年接受教育部重点实验室检验和评估，前两次评估结果均为“优秀”。

　　本实验室根据国家需求和专家组的具体建议，凝练科研方向，加大实验室建设力度，以重大心血管疾病的应用基础研究为总体定位，紧密结合临床问题，以研究代谢性心血管病为主的转化研究为研究方向，针对国人心血管发病的特点，从代谢紊乱入手，深入探索代谢性心血管病的致病因素、发病机制、保护机制和防治靶点。通过全体共同努力和依托单位的高强度支持，重点实验室正在全面步入相关国际领域的中上水平。

　　目前实验室成员52人，独立PI共30人。专业方向涵盖心血管临床、流行病学、病理生理、生物化学和分子生物环境、药理和生物信息学等各个方面。包括1名科学院院士、2名工程院院士、4名长江特聘教授、5名杰出青年基金获得者、7名优秀青年基金获得者、3名中组部“万人计划”青年拔尖人才获得者，2名教育部青年长江学者获得者，1个教育部首届心血管研究的“创新团队”（2004年）、1个基金委创新研究群体（2008年）、8名教育部新世纪优秀人才、4名北京市科技新星在内的高水平的精干研究团队。

　　实验室面积约3534 M²，在国家“985”项目经费的资助下，分别从结构、功能、代谢、组学、信息、模型、临床等方面相继搭建了八大公共平台，50万元以上的仪器设备十余台，总价值约3000万。重点实验室公共平台始终以“服务科研、开放使用”为运行宗旨，在首要满足重点室科研需求的前提下，所有仪器设备全部对外开放共享。 

　　近年来实验室获得2项国家科学技术进步奖二等奖，1项国家自然科学奖二等奖，6项省部级一等奖，4项省部级二等奖，1项中华科技奖二等奖，2项华夏医学科技奖一等奖，3项药明康德生命化学研究奖学者奖，1项第十四届“中国青年科技奖”等奖励。

　　近年来实验室发表SCI论文507篇，其中影响因子9以上有50篇，平均IF为4.485，涉及Nat Med，Nat Genet, JACC, Circulation, Cell Research, Circ Res，Blood, Cell Metabolism，Hepatology, Diabetes等国际一流刊物。

　　实验室获得各种科研项目支持多达215项，约30634万。包括17项基金委重点项目，1个基金委重大项目牵头人，1个基金委重大研究计划培育项目，6个基金委重点研发项目，7个基金委重大研发项目，2个基金委杰青项目，6个基金委优秀青年项目，3项中组部“万人计划”青年拔尖人才项目，1个北京市科技计划-重大项目（1169万）及一项美国NIH1RO1的5年期总经费为173万美元的随机对照人群研究项目。重点实验室PI多次参与临床指南及国家十一五至十三五规划制定。

　　近年来，实验室培养了一批国内心血管的骨干中青年人才，正是通过他们的努力，本实验室才得以在国际舞台上崭露头角。目前完善的心血管功能分析、代谢组学及生物医学信息学平台等成为中国开展代谢性心血管基础研究的主要基地。

　　

　　机构负责人：董尔丹

　　联系人：季亮

　　邮箱：jiliang@bjmu.edu.cn

　　电话：01082805451

　　地址：北京市海淀区学院路38号

　　网址链接：http://cvkeylabs.bjmu.edu.cn

　　

　　

　　

　　Key Laboratory of Molecular Cardiovascular Sciences, Ministry of Education

　　

　　This laboratory is based on Peking University, its predecessor was founded in 1984, Key Laboratory of Cardiopulmonary Endocrine Regulation Peptide, Ministry of Health. In 1994 it was renamed Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptide, Ministry of Health, which was China's first cardiovascular key laboratory, and was established in 2002 as Key Laboratory of Molecular Cardiovascular Sciences, Ministry of Education. The lab is one of the most influential and longest history laboratories in the cardiovascular field of cardiovascular active peptides, adrenaline receptors and metabolic nuclear receptors.

　　Among them, the innovative group of the fund committee for metabolic cardiovascular diseases composed of the main PI has been successively funded twice, which has become the main base of basic research on cardiovascular metabolic diseases in China. The laboratory was inspected and evaluated by the Ministry of Education in 2005, 2010 and 2016. The results of the previous two evaluations were "excellent".

　　Based on the national needs and the specific recommendations of the expert group, this laboratory consolidates scientific research directions, increases laboratory construction efforts, takes the overall application of basic cardiovascular disease research as a whole orientation, and closely integrates clinical problems, the study focuses on metabolic cardiovascular disease-based translational research, it addresses the characteristics of cardiovascular disease in the Chinese population, starts with metabolic disorders, and further explores the pathogenic factors, pathogenesis, protective mechanisms, and prevention and control targets of metabolic cardiovascular disease. Through the joint efforts of all and relying on the high-intensity support of the unit, the key laboratories are now entering the upper-middle level of the relevant international fields.

　　There are currently 52 lab members and 30 independent PIs. The professional direction covers all aspects of cardiovascular clinical, epidemiology, pathophysiology, biochemistry and molecular biological environment, pharmacology and bioinformatics. Including 1 academician of the Chinese Academy of Sciences (CAS), 2 academicians of the Chinese Academy of Engineering (CAE), 4 distinguished professors of Yangtze River Scholars, 5 winners of the National Science Fund for Distinguished Young Scholors, 7 winners of the National Science Fund for Excellent Young Scholors, 3 winners of the “Millions Plan” youth top talents in the Central Organization Department, 2 winners of the youth of the Yangtze river Scholars, a first cardiovascular research by ministry of education innovation team (2004), a foundation innovation research group (2008),8 New Century Excellent Talents of Ministry of Education,4 Beijing Science and Technology Rising Stars within this high level research team.

　　With a laboratory area of approximately 3,534 M², under the support of the national “985” project, 8 public platforms have been successively constructed in terms of structure, function, metabolism, omics, information, models, and clinical aspects, more than 10 equipment worth  more than 500,000 yuan, the total value of about 30 million yuan. The key laboratory public platform has always been based on " research service, open use" as the operating principle. Under the premise of meeting the research needs of the key room, all instruments and equipment are all open to the outside world.

　　Recent years, laboratory won 2 national prize for science and technology progress prize, 1 second prize of national natural science, 6 provincial first prize, 4 provincial second prize, 1 second prize of China science and technology award, 2 first prize in the Chinese medical science, 3 awards for research in pharmacokinetic biochemistry, 1 item of the 14th "China youth science" and other awards.

　　In recent years, the laboratory published 507 SCI papers, of which there were 50 IF>9, average IF is 4.485, involving Nat Med, Nat Genet, JACC, Circulation,Cell Research, Circ Res, Blood, Cell Metabolism, Hepatology, Diabetes and other international first-class journals.

　　The laboratory has received 215 scientific research projects, about 306.34 million. Including 17 key projects of NFSC, 1 major project leader of NFSC, 1 major research project of NFSC, 6 key research and development projects of NFSC, 7 major research and development projects of NFSC , 2 NSFC outstanding youth program, 6 excellent youth program of the NSFC, 3 youth top-notch talent project of "ten thousand people program" of the Central Organization Department, 1 of Beijing science and technology plan - major projects (11.69 million) and 1 American NIH1RO1 five-year randomized controlled crowd research projects with total funds of $1.73 million. Laboratory PIs have participated in the formulation of clinical guidelines and the national 11th to 13th five-year plans for many times.

　　In recent years, the laboratory has trained a number of young and middle-aged domestic cardiovascular talents. It is through their efforts that the laboratory has been able to emerge on the international stage. At present, the complete cardiovascular function analysis, metabolomics and biomedical informatics platforms have become the main bases for metabolic cardiovascular basic research in China.

　　

　　Director: Er-dan dong

　　Contact: Liang Ji

　　Email: jiliang@bjmu.edu.cn

　　TEL: 010-82805451

　　Address: Xueyuan Road 38, Haidian District Beijing

　　Website：http://cvkeylabs.bjmu.edu.cn