国家卫生健康委员会医学免疫学重点实验室于1995年10月由卫生部批准建立，直接委托单位是北京大学医学部（原北京医科大学）。2000年4月3日，北京大学与原北京医科大学合并，组建了新的北京大学。北京大学为教育部直属全国重点大学，国家“211工程”、“985工程”建设大学。

      医学免疫学重点实验室先后由龙振洲（1995-1997）、马大龙（1997-2002）、高晓明（2002-2010）、张毓（2010-2017）和邱晓彦（2017-至今）教授担任实验室主任，陈慰峰教授（1995-2009）和田志刚教授（2009-至今）任学术委员会主任。现任实验室主任邱晓彦教授。

      医学免疫学重点实验室主要研究方向和内容包括：（1）免疫细胞发育与分化，聚焦于免疫细胞在不同免疫器官、在免疫重建过程中及相应免疫性相关疾病条件下的发育、分化及其分子调控机制；（2）免疫功能基因组学，研究新细胞因子、免疫膜分子、自噬相关分子在免疫细胞发育、感染、自身免疫病以及肿瘤发生、发展、治疗和预后分析中的作用；（3）非B细胞来源的Ig（non B-Ig）研究，探索non B-Ig的结构、功能、生理、病理意义，进行以non B-Ig作为新靶点的转化医学研究；（4）肿瘤免疫，鉴定新的肿瘤特异抗原及抗原表位，研发新的CAR-T细胞及TCR-T细胞等免疫治疗的新手段和方案。

    医学免疫学重点实验室面积约2100M2，装备有免疫学、细胞生物学和分子生物学研究的基本仪器设备，包括分析型流式细胞仪、细胞分选仪、全自动DNA序列分析仪、毛细管电泳仪、定量PCR仪、高压液相色谱仪、酶联斑点图像分析系统、倒置荧光显微镜、显微图像分析系统、低压层析系统、紫外分光光度计、发酵罐、各种离心机、SPF级小鼠饲养设施、活细胞工作站和在体成像技术平台。

       重点实验室发展目标是，创造良好的科学研究条件和学术环境，吸引和聚集国内外优秀人才，在医学免疫学的前沿领域开展高水平的基础和应用研究，促进新兴、交叉学科的形成和发展，培养和造就高层次的科技人才，办成具有国际水平的医学免疫学研究中心和高层次人才培养基地。

       医学免疫学重点实验室固定人员30人，其中教授9人，副教授9人，研究员1人，副研究员1人，技术辅助人员10人。人才队伍中包括长江学者和杰出青年基金获得者1 人（张毓）；新世纪优秀人才4 人（韩文玲、葛青、王月丹、张君）；优青1 人。引进新体制研究员1人，副研究员1人。

近年来的重要科研成果及贡献：

首次发现非B细胞可以表达Ig（non B-Ig），系统研究了其遗传学特征及生理病理意义，发现non B-Ig可变区呈现非多样性，其产生不依赖RAG基因重排；non B-Ig具有天然抗体活性，在皮肤黏膜免疫中发挥防御作用；non B-Ig在心肌、肝细胞及生精细胞中具有重要的生理功能；non B-Ig在促进肿瘤的发生、转移和炎-癌转化等过程中发挥关键作用，已在Cancer Research、Leukemia、J Biol Chem等国际权威杂志发表论著20余篇，获得多项专利授权，开辟了肿瘤免疫学non B-Ig研究的新领域。相关研究得到了国家自然科学基金重点项目、重大国际合作项目、国家自然科学基金面上项目等多项国家级基金的资助。

机构负责人：邱晓彦

联系人：张岩

邮箱：qiuxy@bjmu.edu.cn；onlyzhangyan@126.com

电话：82805477；82801694

地址：北京市海淀区学院路38号北京大学医学部中心楼5-7层

 

 

NHC Key Laboratory of Medical Immunology

The Key Laboratory of medical immunology of the National health Commission was established in October 1995 with the approval of the Ministry of Health, directly subordinate to the Peking University Healthy Science Center (formerly Beijing Medical University). On April 3, 2000, Peking University and the former Beijing Medical University merged to form a new Peking University. Peking University is a national key university directly under the management of Ministry of education and a national "211 Project" and "985 Project" construction university.

Previous laboratory directors include Professor Zhenzhou Long (1995-1997), Professor Dalong Ma (1997-2002), Professor Xiaoming Gao (2002-2010), Professor Yu Zhang (2010-2017) and Professor Xiaoyan Qiu (2017 present). Professor Weifeng Chen (1995-2009) and Professor Zhigang Tian (2009 present) served as the director of the academic committee. Now professor Xiaoyan Qiu works as director of the laboratory.

The main research directions and contents of the Key Laboratory of medical immunology include: (1) the development and differentiation of immune cells, focusing on the development, differentiation and molecular regulatory mechanism of immune cells in different immune organs, in the process of immune reconstruction and under the conditions of immune-related diseases; (2) the Research of immune functional genomics, studying new cytokines, immune membrane molecules and autophagy related points; (3) The research of non-B-Ig, immunoglobulin from non-B cell source, to explore the structure, function, physiological and pathological significance of non-B-Ig, to carry out non-B-Ig as a new target of translational medicine research; (4) Tumor immunity, identification of new tumor specific antigens and epitopes, research and development of new CAR-T cells and related immunotherapy methods and plans.

The Key Laboratory of medical immunology covers an area of about 2100m2and is equipped with basic instruments and equipment for immunology, cell biology and molecular biology research, including analytical flow cytometer, cell sorter, automatic DNA sequence analyzer, capillary electrophoresis, quantitative PCR, high-pressure liquid chromatography, enzyme-linked spot image analysis system, inverted fluorescence microscope and microscopic image analysis System, low-pressure chromatography system, UV spectrophotometer, fermentation tank, various centrifuges, SPF mouse feeding facilities, living cell workstation and in vivo imaging technology platform.

The development goal of the key laboratory is to create good scientific research conditions and academic environment, attract and gather excellent talents at home and abroad, carry out high-level basic and applied research in the frontier field of medical immunology, promote the formation and development of new and interdisciplinary subjects, train and train high-level scientific and technological talents, and build an international level medical immunology research center and high-level medical immunology research center Level talent training base.

There are 30 fixed staff in the Key Laboratory of medical immunology, including 9 professors, 9 associate professors, 1 researcher, 1 associate researcher and 10 technical assistants. The talent team includes 1 Yangtze River scholar and outstanding youth fund winner (Yu Zhang); 4 new century outstanding talents (Wenling Han, Qing Ge, yuedan Wang, Jun Zhang); 1 Winner of Excellent Youth Fund. One researcher and one associate researcher of the new system were introduced.

Significant achievements in recent years：

non-B-Ig were first reported by Professor Qiu Xiaoyan three decades ago that non-B cells can express Ig, following systematically studies focus on its genetic characteristics and physiological and pathological significance. It was found that the variable region of non-B-Ig showed little diversity, and its production did not depend on the rearrangement of RAG gene. Non-B-Ig had natural antibody activity, and played a defensive role in skin mucosal immunity; Non-B-Ig played an important role in physiological function of myocardium, liver cells and spermatogenic cells. Non-B-Ig plays a key role in promoting the occurrence, metastasis and transformation of tumor. More than 20 works has been published incancer research, leukemia, J Biol Chem and other international authoritative magazines, obtaining a number of patent authorizations, and a new field of non-B-Ig research was opened up in tumor immunology. Relevant research has been supported by NSFC key projects, major international cooperation projects, NSFC general programs and other national funds.

 

Director: Xiaoyan Qiu

Contact: Yan Zhang

Email: qiuxy@bjmu.edu.cn；onlyzhangyan@126.com

TEL: 82805477；82801694

Address: Department of Immunology, School of Basic Medical Sciences, NHC Key Laboratory of Medical Immunology, Peking University, Beijing, China