国家卫生健康委员会精神卫生学重点实验室

   

  卫生部精神卫生学重点实验室是国内唯一的一家部级精神病学科重点实验室,成立于1993年,沈渔邨院士任第一届重点实验室主任。2011年底顺利通过了卫生部评估。

  多年来随着医学模式的转变以及医学科学发展的趋势,重点实验室以我国人群患病率最高和危害性最大的精神疾病为研究重点,逐渐形成临床精神病学、社会精神病学、生物精神病学三个稳定的研究方向。临床精神病学重点开展生物学诊断研究以及个体化药物治疗和心理治疗;社会精神病学方向利用现场人群大数据调查获取精神疾病流行病学资料和患病环境风险因素;生物精神病学方向则借助多学科研究技术方法探讨重大精神疾病的发病机理。各个研究方向努力将所获得的新理论、新技术、新方法转化成对重大精神疾病发病机制、诊断和新药物靶点寻找的适用研究,以促进相关临床问题的解决。

   卫生部精神卫生学重点实验室实行PI负责制,各项制度健全。重点实验室现有科研人员73名,目前有沈渔邨、陆林两位院士,以及王玉凤、张岱、黄悦勤、于欣、司天梅、岳伟华、王华丽、钱秋谨、孙洪强等教授为学术带头人的科研团队,主要从事精神疾病的临床和基础研究工作。以院士、国家百千万人才、“973”计划及基金委创新群体首席科学家、长江学者计划特聘教授、国家杰出青年及优秀青年科学基金获得者、教育部新世纪优秀人才、博士生导师为学术带头人,中国科协青年托举工程人才、北京市科技新星、北京市“十百千”优秀卫生人才等科研人员为骨干的年龄结构合理、创新能力强的临床研究梯队。重点实验室占地1200平方米,,拥有大型科研仪器设备130余台,建立了精神疾病生物标记物评价平台、脑电监测系统以及病理性记忆动物模型研究平台等研究平台,牵头承担了多项国家重点研发计划、“973”计划、“863”计划、支撑计划、国家自然科学基金创新群体及重点项目等国家级重大课题,在Science、Nat Genet、Lancet、Nat Neurosci、Am J Psychiatry、JAMA Psychiatry、Mol Psychiatry、PNAS等权威杂志发表了系列研究论著,获得国际同行的多次专题评论和广泛重复、引用,在国际上产生了重要的学术影响。研究团队获得了教育部科学技术进步奖、北京市科学技术奖、中华医学科技奖、华夏医学科技奖等多项奖励。2015-2017连续三年获得中国科技影响力排行榜精神病学学科第一,北京大学精神病学/心理学进入全球基本科学指标数据库(ESI)前1%,成为国际高水平学科之一。

  重点实验室开展了系列精神心理疾病应用基础研究,在国际上产生重要的学术影响。对精神分裂症、注意缺陷多动障碍、抑郁症、孤独症、成瘾等疾病进行的研究,取得了丰硕成果,如首次在国际上报道唤起-消退模式可以消除病理性记忆,为成瘾及其他疾病的治疗提供了新的方向,报道中国汉族人群精神分裂症易感基因并深入探索新型易感基因的潜在功能,采用影像遗传学手段发现注意缺陷多动障碍受遗传因素影响的脑影像学特征与药物疗效显著关联。卫生部精神卫生学重点实验室努力建成国家级转化医学研究平台,倡导以患者为中心,从临床工作中发现和提出问题,进行深入的基础研究,然后再将基础研究成果快速转向临床应用,以提高医疗总体水平,最终使患者受益。实验室将努力缩短中国与世界在精神病学研究领域的差距,大力发展精神疾病转化医学,促进基础研究与我国病例资源优势的整合,快速提升我国重大精神疾病诊断和干预技术研发的原始创新能力,并在重大精神疾病发病机制上取得突破性进展。

 

  Brief introduction of Key Laboratory of Mental Health, Ministry of Health

  The Key Laboratory of Mental Health, Ministry of Health is the only Key Laboratory of Psychiatry in China. It was established in 1993, and the Academician Yucun Shen is the first director of key laboratory. The key laboratory was successfully passed the assessment of Ministry of health at the end of 2011.

  For many years, with the transformation of medical model and the trends of development in medical science, the Key Laboratory focused on the highest prevalence rate and the most harmful mental disorders in China, and gradually formed three stable research directions including clinical psychiatry, social psychiatry, and biological psychiatry. The research of clinical psychiatry focus on biological diagnosis, individualized drug therapy and psychotherapy; the social psychiatry obtaine the epidemiological data of mental disorders and environmental risk factors by using large data survey of people in the field; the biologic psychiatry investigate the pathogenesis of major mental diseases by the means of multidisciplinary research techniques. To promote the resolution of related clinical problems, researchers in all directions are trying to explore the pathogenesis, diagnosis and novel drug targets of major mental diseases.

  The Key laboratory was executing the responsibilities of principle investigators with rules and regulations. There are 73 research personnel in the Key Laboratory now, including two academicians Yucun Shen and Lin Lu, and Professors Yufeng Wang, Dai Zhang, Yueqin Huang, Xin Yu, Tianmei Si, Weihua Yue, Huali Wang, Qiujin Qian and Hongqiang Sun as the academic leader of the research teams. They are mainly engaged in the clinical and basic research work of mental illness. The key laboratory established a clinical research echelon with reasonable age structure and strong innovation ability which includes the Academicians, the National Millions Talent, the chief scientist of Foundation for Innovative Research Groups of the National Natural Science Foundation of China and the State Key Development Program for Basic Research of China (973), the Yangtze river scholars Distinguished Professor, Winners of National Natural Science Foundation of China for Distinguished Young Scholars and National Natural Science Foundation of China for Outstanding Young Scholars, the New Century Excellent Talents in University and PhD supervisors as the academic leaders, and the Supported Young talent by the association for science and technology of China, the winner of the Science and Technology Nova Plan and Beijing ten hundred thousand excellent health professionals as key members. The Key laboratory covers an total area of 1200 m2, more than 130 large research apparatus, and established mental disease biomarker evaluation platform, EEG monitoring system and pathological memory animal model research platform etc. The members take the lead to charge multiple items of national major Projects including National key research and development program, State Key Development Program for Basic Research of China (973), National High Technology Research and Development Program of China (863), National Science & Technology Pillar Program, and the Foundation for Innovative Research Groups of the National Natural Science Foundation of China etc. The members have published a series of research papers in many famous journals including Science, Nat Genet, Lancet, Nat Neurosci, Am J Psychiatry, JAMA Psychiatry, Mol Psychiatry and Proc Natl Acad Sci USA. These published papers had gained many special comments and extensive repetition and citations from international counterparts, which generated important academic influences in the worldwide. The research team won many awards, such as the science and technology progress award of the Ministry of education, the Beijing prize for science and technology, the Chinese medical science and technology award, the Chinese medical science and Technology Award and so on. During the three consecutive years from 2015 to 2017, the institute won the first position of China's science and technology influence list of psychiatry, and the Psychiatry / Psychology of Peking University has entered the first 1% of the global basic scientific index database (ESI), and has become one of the international high level disciplines.

  The key laboratory has performed a series of applied basic researches on mental and psychological diseases, which has an important academic influence in the worldwide. The studies on diseases such as schizophrenia, attention deficit hyperactivity disorder (ADHD), depression, autism and addiction achieved fruitful results. For example, the members first reported the elimination of pathological memory by evocation-extinction patterns providing a new direction for the treatment of addiction and other diseases, reported schizophrenia susceptibility genes in Chinese Han population and explored the potential function of these new susceptibility genes, and found the significant association between drug efficacy and brain imaging characteristics affected by genetic factors in ADHD. The researches in key Laboratory try to build it as a national platform of translational medicine research, advocate taking patients as the center, and finding and putting forward problems from clinical work, conducting in-depth basic research, and then turning the basic research results into clinical application quickly, to improve the overall level of medical treatment, and ultimately benefit patients. The laboratory will try to shorten the gap between China and the world in the field of psychiatric research, vigorously develop the translational medicine of mental diseases, promote the integration of basic research and case resources in China, rapidly improve the original innovation ability of major mental disease diagnosis and intervention technology research in China, and achieve a breakthrough in the pathogenesis of major mental illness.