北京大学第三医院运动医学实验室是依托北京大学医学部及北京大学第三医院的平台建立，并于2013年6月被北京市科委正式认定为北京市运动医学关节伤病重点实验室，现任重点实验室主任为北京大学第三医院运动医学研究所所长敖英芳教授，学术委员会主任为中国工程院院士邱贵兴教授，副主任为北大信科院院长黄如院士。

　　实验室针对运动医学领域的常见伤病及疑难疾病，以发病机制、诊治技术、康复预后为研究基础，围绕运动医学发展过程中的重要科学问题，开展与运动伤病相关的基础与临床应用研究、组织工程修复与临床转化研究以及微创治疗。实验室的主要研究方向及研究内容包括:1.关节运动伤病的诊疗技术及相关基础研究；2.退行性关节疾病的发病机制、新的治疗靶点及诊疗技术的研究；3.软骨、半月板、韧带等组织工程技术与基因诊疗技术在运动伤病防治中的研究；4.运动对人体生理生化与机能影响的研究；5.运动伤病术后的功能评定和康复研究。经过多年的建设，实验室已形成包括分子生物学、细胞生物学、组织病理学、生物力学、分子影像学、材料学及工学、组织工程学等多学科、多角度综合科研平台，同时在疾病分子机制、表观遗传、生物力学、3D生物打印组织工程、康复策略、临床试验及转化研究等方面积累了厚实的基础。

　　经过60年的建设，运动医学研究所已成为一支整体素质高、实力强的学术梯队。目前运动医学研究所在编职工73人，其中有博士学位者29人，正高职称12人，副高职称20人，其中博士生导师4名，硕士生导师5名。目前实验室面积有2000余平方的专用面积，3000余万元专用设备。实验室目前科研基金项目达80余项，承担研究经费达7000余万元；近五年来实验室的研究成果先后在运动医学相关领域刊物发表SCI论文100余篇，影响因子最高为 19.79。获国家专利28 项，主编专著13 部，获4 项省部级一等奖。建立全国运动伤病防治体系，制定国家内镜诊疗规范指南与运动医学专科培养方案，培养学科骨干4500 人，推广微创技术至全国32个省区445家医院，诊治患者200万人，为运动医学发展与健康中国建设做出了突出贡献。

　　近年来重要科研成果及贡献：创建运动伤病精准微创外科治疗体系并应用；系统研究膝关节前交叉韧带断裂关节不稳继发损害的规律及其运动生物力学机制，率先开展运动伤病脑科学研究发现膝关节不稳对脑中枢的影响；深入研究运动损伤修复与重建再生机制，国际首次发现关节软骨退变早期细胞线粒体存在“超氧炫”现象，合成偶联ADAMTS-4 特异多肽的新型纳米金颗粒探针，创建软骨损伤早期诊断方法；阐明多个关键非编码RNA 在关节退变中的作用机制；筛选出干细胞亲和多肽E7、L7，阐明结构与功能优化生物材料在组织修复再生中作用机制，提出利用局部自体干细胞原位、一次性修复软骨等组织的创新理论。在北京大学、北京大学医学部与北京大学第三医院的有力支持下，实验室将努力在前沿科技领域开展创新性研究，获取具有自主知识产权的创新成果，培养和凝聚创新性人才，构建高水平实验技术和国际学术交流平台，为国家的运动医学事业做出更大的贡献。

　　

　　机构负责人：敖英芳

　　联系人：胡晓青

　　邮箱：huxiaoqingbd01@sina.com

　　电话：82265731

　　地址：北京市海淀区花园北路49号北京大学第三医院药学楼

　　

　　

　　Beijing Key Laboratory of Sports Medicine Joint Injury

　　The Sports Medicine Laboratory of Peking University Third Hospital of was established on the platform of the Peking University Health and Science Center and Peking University Third Hospital. In June 2013, it was officially recognized by the Beijing Municipal Science and Technology Commission as the key laboratory for joint injury and sports medicine. The director of the Key Laboratory is Prof. Yingfang Ao, director of the Sports Medicine Institute of Peking University Third Hospital. The director of the Academic Committee is Professor Guixing Qiu, the academician of the Chinese Academy of Engineering, and the deputy director of the Academic Committee is Prof. Ru Huang, the academician of Chinese Academy of Science and Dean of Peking University.

　　The laboratory aims at the common injuries and refractory diseases in the sports medicine. Based on the pathogenesis, diagnosis and treatment techniques, and rehabilitation prognosis, we carried out researches focusing on the basic and clinical applications of sports injuries and treatment, tissue engineering and clinical translational research, and minimally invasive treatment to solve key scientific issues in the development of sports medicin,. The main research directions and research contents of the laboratory include: 1. Diagnosis and treatment techniques for joint injuries and related basic research; 2. The pathogenesis, new therapeutic targets and research techniques of degenerative joint diseases; 3. Tissue engineering technology (cartilage, meniscus, ligament) and gene diagnosis and treatment techniques in the prevention and treatment of sports injuries; 4. The effects of exercise on human physiology and biochemistry and function; 5. Functional assessment and rehabilitation study of sports injury after surgery. After years of construction, the laboratory has formed a multidisciplinary and multi-angle comprehensive scientific research platform including molecular biology, cell biology, histopathology, biomechanics, molecular imaging, materials science and engineering, tissue engineering, etc. Also, we have accumulated a solid foundation in molecular mechanisms, epigenetics, biomechanics, 3D bioprinting tissue engineering, rehabilitation strategies, clinical trials and translation studies.

　　After 60 years of construction, the Institute of Sports Medicine has become an academic echelon with strong strength and high overall quality. At present, the Institute of Sports Medicine has 73 staff members, including 29 doctoral candidates, 12 with high professional titles, and 20 with associate professional titles, and including 4 doctoral supervisors and 5 master supervisors. The current laboratory has a dedicated area of ？？more than 2,000 square meters and more than 3,000 yuan worth of special equipment. At present, there are more than 80 scientific research fund projects in the laboratory, and the research funding has reached more than 7,000 million; over the past five years, the laboratories have published more than 100 SCI papers in sports medicine-related fields. The highest impact factor is 19.79. We have won 28 national patents, edited 13 monographs and won 4 provincial and ministerial awards. We have established a national sports injury prevention and control system, formulate national guidelines for endoscopic diagnosis and treatment and training programs for sports medicine, trained 4,500 professional doctors, and promoted minimally invasive techniques to 445 hospitals in 32 provinces and regions, treated 2 million patients for sports.

　　Important scientific research achievements and contributions in recent years：Created a precise minimally invasive surgical treatment system for sports injuries and apply it. Systematically studied the pathology of secondary damage of the anterior cruciate ligament of the knee joint and the biomechanical mechanism of movement. Taken the lead in carrying out brain research on sports injuries to find that knee instability’s influence of the brain center. Carried out in-depth study of the mechanism of sports injury repair and reconstruction. Found that articular cartilage degeneration has "superoxide dazzle" phenomenon in the mitochondria for the first time in the world, Synthesized a new nanoparticle probe coupled with ADAMTS-4 specific peptide to create early diagnostic methods for cartilage injury. Elucidated the function and mechanism of several key non-coding RNAs in joint degeneration. Screened out stem cell affinity polypeptides E7, L7. Explained the mechanism of structural and functional optimization of biological materials in tissue repair and regeneration. Proposed an innovative theory of one-step surgery using autologous stem cells in situ to repair cartilage and other tissues. With the strong support of Peking University, Peking University Health and Science Center and Peking University Third Hospital, the laboratory will strive to carry out innovative researches in frontier science and technology fields to obtain innovative results with independent intellectual property rights, cultivate and condense innovative talents, build high-standard experimental technology and international academic exchange platform and make greater contribution to the national sports medicine.

　　

　　Director:  Yingfang Ao

　　Contacts:  Xiaoqing Hu

　　E-mail: huxiaoqingbd01@sina.com

　　Phone Number: (+86)010-82265731

　　Address: Pharmaceutical Building, Peking University Third Hospital, 49 North Garden Road, Haidian District, Beijing