神经系统小血管病探索北京市重点实验室依托于北京大学第一医院组建，2013年6月被北京市科委正式认定，现任重点实验室主任为黄一宁教授。

　　实验室的研究领域和方向为，综合利用影像学、病理学、血液动力学、生物医学信息、基因分析、蛋白和脂质亚型谱分析等技术，对神经系统小血管病的遗传学、血管自动调节、脑组织灌注、内皮细胞功能、脑组织氧代谢等领域进行多方面的深入研究。开发影像、脑血流分析技术，探索干预技术，促进转化医学研究。

　　实验室现有42 名研究人员，27人有高级职称，其中博士生导师3人，硕士导师20人。实验室占地面积1500m²，建立了脑小血管病生物标本库。具备神经病理、神经生化、神经免疫学和分子生物学和小血管病可视化成像平台。

　　本实验室注重开放交流，已经与悉尼大学乔治中心、德国Ulm大学、美国Duke大学、北京大学工学院、北京大学分子医学研究所、中科院化学所、北京大学医学部基础医学院等多家医疗科研机构开展临床及科研合作。研究脑与神经肌肉小血管病发病机制、致病原因，建立小血管病诊断和治疗新方法、新技术的平台。并将结果转化应用于临床。

　　近年来，实验室在神经系统小血管病的基础和临床研究取得了一系列成果。牵头撰写了中国脑小血管病诊治共识。牵头高质量的多中心临床试验，包括西洛他唑对缺血性卒中的临床试验、国际性脑出血急性期的紧急快速降压干预研究。基础研究包括脂质谱对血管内皮功能的影响、pH场敏感载尿激酶纳米体系的构建、中国遗传性脑小血管病的遗传研究。研究成果发表在《The Lancet Neurology》、《Neurology》、《Stroke》、《J Neurol Neurosurg PsychiatryNeurology》等顶级期刊，并在国际著名大学和会议上报告。获得教育部自然科学奖二等奖，中华医学科技奖三等奖,北京市科学技术奖三等奖。

　　

　　机构负责人：黄一宁

　　联系人：王朝霞

　　邮箱：drwangzx@163.com

　　电话：010-83575783

　　地址：北京市西城区西什库大街8号

　　

　　

　　Neurovascular Disease Discovery Laboratory,Beijing (NDDL)

　　(Peking University First Hospital)

　　Neurovascular Disease Discovery Laboratory, Beijing (NDDL) supported by PekingUniversityFirstHospital, was established and officially certificated by Beijing Municipal Science and Technology Commission in June, 2013. The present director of the key laboratory is Prof. Huang Yi-ning.

　　The research area of the laboratory is covering multiple fields in small vascular disease of nervous system, including genetics, vascular auto-regulation, brain tissue perfusion, endotheliocyte function, cerebral tissue oxygen metabolism, etc. The research methods include radiology, pathology, hemodynamics, biological medical informatics, genetic analyses, proteomics and lipidomics analyses, etc. The goal of the laboratory is to develop radiological and cerebral hemodynamic techniques, and to explore intervention technology in order to promotetranslational medicine research.

　　The laboratory is composed of 42 researchers, of whom 27 are of senior titles, 3 are doctoral supervisors and 20 are master supervisors. The building area of the laboratory is 1500 m², including a cerebral small vascular disease biobank and an integration platform on neuropathology, neurobiochemistry, neuroimmunology, molecular biology and visual imaging of cerebral small vascular disease.

　　The laboratory focuses on international and domestic communications. Up to now, we have built long-term clinical and research corporations with a number of medical and research institutions, including George Institute for Global Health,University of Sydney, Ulm University, Duke University, College of Engineering,Peking University, Institute of Molecular Medicine, Peking University, Institute of Chemistry Chinese Academy of Sciences, Peking University School of Basic Medical Sciences, etc. The common goal is to investigate the etiology and pathogenesis of cerebral and neuromuscular small vascular diseases, establish a platform with innovative methods and techniques on the diagnosis and treatment of small vascular disease, and finally translate research results into clinical application.

　　In recent years, a series of achievements have been made in the basic and clinical researches on small vascular disease of nervous system. We took the lead in the accomplishment of the Chinese Consensus on Cerebral Small Vascular Disease. We have also organized several multicenter clinical trials of high quality as the leading member, including the clinical trial of effect of cilostazol on ischemic stroke, world clinical trial - rapid blood pressure lowering in patients with acute cerebral hemorrhage(INTERACTⅠ). The basic scientific researches of the laboratory include the influence of lipidomics on endotheliocyte function, PH field sensitive urokinase nanoscale system, and the study on the genotype and phenotype spectrum of Chinese patients with CADASIL and MELAS. The research achievements were published on a number of top journals, including The Lancet Neurology , Neurology , Stroke , Journal of Neurology Neurosurgery and Psychiatry Neurology , etc. and were reported in world famous universities and on international meetings. The laboratory was awarded second prize of Natural Science of Ministry of Education, third prize of Chinese Medical Science Award, and third prize of Beijing Science and Technology Award.

　　

　　Director:：Huang yi-ning

　　Contact:Wang zhao-xia

　　E-mail: drwangzx@163.com

　　Phone: 010-83575783