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首页 > 基地平台 > 机构列表 > 国家中医药管理局重点研究室/实验室
 
国家中医药管理局中药药理 (肿瘤) 三级实验室
发布日期:2018-03-21浏览次数:字号:[ ]

   

  本实验室是在中西医结合科研究室的基础上成立的,于2009.7通过国家中医药管理局三级实验室认证,得到了多项国家级、省部级课题的资助,培养了多名博士和硕士研究生。

  研究领域主要集中在中药对乳腺癌和肺癌的治疗作用和机制研究。研究方向:

  1. 舒肝凉血治则调节雌激素代谢的作用机理研究

  2. 清热解毒中药改善肿瘤耐药的机制研究

  3. 肿瘤微环境及中药的调节作用

  本实验室的技术人员来自细胞生物学、免疫学、药学和肿瘤学专业,学科交叉特点显著。在李萍萍教授的带领下,结合临床问题,进行了中药调节肿瘤微环境及中药抗肿瘤作用机制的研究。团队的研究成果“乳腺癌内分泌治疗不良反应的中药干预效果与机理研究”获得了2012年教育部科学技术进步奖二等奖,所应用的中药方剂已申请了国家发明专利并获授权。

  李萍萍教授的临床经验方——舒肝凉血方经临床试验表明具有改善乳腺癌内分泌治疗所致潮热、失眠等副作用,实验室研究结果证实了该方能抑制雌激素相关合成酶的合成和代谢,具有抑制肿瘤生长的作用,不干扰内分泌治疗药物的疗效且具有协同作用。补肺方常用于改善肺癌患者肺气不足的症状,实验室研究表明该方对肿瘤免疫微环境具有调节作用。上述研究均为从临床发现问题,通过实验室研究为中医药治疗肿瘤的临床应用提供科学依据,具有重要的临床意义。

  

  机构负责人:李萍萍教授

  联系人:韩淑燕

  邮箱:shuyanhan@126.com

  电话:010-88196706

  地址:北京市海淀区阜成路52号

  

  

  Pharmacology (tumor) third-level laboratory of State Administration of Traditional Chinese Medicine

 

  This laboratory was established on the basis of the Laboratory of Integrative Medicine Department, and passed the third-level laboratory accreditation of the State Administration of Traditional Chinese Medicine in July 2009. It has obtained funding support from National Natural Science Foundation of China, Beijing Municipal Natural Science Foundation, projects from Beijing Municipal Administration of traditional Chinese Medicine, and so on. This platform also has educated more than a dozen of Ph.D and Master candidates.

  The research field of this lab mainly focuses on the anti-tumor effects and mechanism elucidation of traditional Chinese medicine on breast cancer and lung cancer.Research directions:

  1. Mechanisms elucidation of Shu-gan-liang-xue therapeutic principle on estrogen metabolism regulation.

  2. The mechanisms of overcoming drug resistanceby Chinese herb with clearing heat and removing toxicity effect.

  3. Tumor microenvironment and the regulation effect of traditional Chinese medicine.

  The researchers of this laboratory are with different educate background such as cell biology, immunology, pharmacy and oncology, so this lab has remarkable interdisciplinary characteristics. With the leading of Professor Li Pingping, the director of our lab, our team conducted research on the regulative effect of Chinese medicine in tumor microenvironment as well as their anti-tumor action evaluation and mechanisms elucidation. Our research projects mainly initiate from clinical issues. Our research team won a Second Class Award of Educational Ministry Science and Technology Improvement in 2012, with the research results titled of "The intervention effect and mechanisms of Chinese medicine on adverse drug reaction caused by breast cancer endocrine therapy". In addition, the Chinese medicine prescription which has been used in clinics to ameliorate endocrine therapy caused side effect has applied for anational invention patentand be authorized.

  Shu-gan-liang-xue decoction, the experienced prescription of Professor Li Pingping in clinical settings, was demonstrated to ameliorate side effects such as hot flash, insomniacaused by endocrine therapy for breast cancer. The laboratory studies showed this decoction can inhibit the synthesis and metabolism of estrogen-related enzymes thus to reduce tumor growth. Moreover, this decoction does not interfere with the efficacy of endocrine drugs but shows a synergistic effect with it. Bufei dedoction was commonly used to tonifying Qi for lung cancer patients with lung-Qi deficiency symptoms in clinics, and our laboratory studies showed this decoction can regulate the tumor immune microenvironment to exert anti-tumor efficacy. Our studies mostly come from the clinical issues, and provide scientific evidence and support for traditional Chinese medicine to treat cancer through laboratory research. Therefore, our experimental studies have been important clinical significance.

  

  Director of Lab: Professor Li Pingping

  Contact Person: Han Shuyan

  E-mail: shuyanhan@126.com

  Tel: 010-88196706

  Address: 52 Fucheng Road, Haidian District, Beijing




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